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KMID : 0604020160310020146
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Korean Journal of Critical Care Medicine
2016 Volume.31 No. 2 p.146 ~ p.151
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Lung Transplantation for Chronic Humidifier Disinfectant-Associated Lung Injury
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Kim Won-Young
Kim So-Woon
Jo Kyung-Wook
Choi Sae-Hoon
Kim Hyung-Ryul
Kim Yong-Hee
Kim Dong-Kwan
Park Seung-Il
Hong Sang-Bum
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Abstract
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In the spring of 2011, a cluster of lung injuries caused by humidifier disinfectant (HD) usage were reported in Korea. Many patients required mechanical ventilation, extracorporeal membrane oxygenation, and even lung transplantation (LTPL). However, the long-term course of HD-associated lung injury remains unclear because the majority of survivors recovered normal lung function. Here we report a 33-year-old woman who underwent LTPL approximately four years after severe HD-associated lung injury. The patient was initially admitted to the intensive care unit and was supported by a high-flow nasal cannula. Although she had been discharged, she was recurrently admitted to our hospital due to progressive lung fibrosis and a persistent decline in lung function. Finally, sequential double LTPL was successfully performed, and the patient’s clinical and radiological findings showed significant improvement. Therefore, we conclude that LTPL can be a therapeutic option for patients with chronic inhalation injury.
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KEYWORD
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disinfectants, humidifiers, inhalation exposure, lung transplantation, oxygen inhalation therapy
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